While conventional topical creams are obstructed from passing through the lipid layer of the skin, our transdermal formulation enables our nano-sized CBD particles to penetrate quickly and interact with the body’s natural receptors.
- THC free (tested at 20 ng/mL)
- Transdermal formulation for deeper penetration
- Fast acting
- Third-party tested
What’s the Difference Between a Transdermal CBD Cream and a Topical CBD Cream? While both compounds are applied to the skin, only transdermal CBD formulations are designed for maximum absorption through the skin to affect deeper or more distant tissues. Topical CBD formulations are known to only minimally penetrate the skin whereas BioNan-X Cool Relief Transdermal Cream with nano-amplified CBD penetrates the entire lipid layer quickly for maximum absorption into the bloodstream for immediate effect.
- Size per Pack: 2 mL
- No. of Sample Packs: 3
- Amount Per Pack: 16 mg
Suggested Use: Apply to clean, dry skin every 4 to 6 hours or as needed.
Warnings: For external use only. Use only as directed. Avoid contact with eyes. Do not apply to open wounds or use with heating pad. Stop use and consult a doctor if skin redness or skin irritation develops or if condition worsens. Do not use if pregnant or breastfeeding. Keep out of reach of children. If swallowed seek medical care or contact a Poison Control Center right away. Consult a doctor if under 18 years of age. Store at room temperature.
Active Ingredient: Menthol 1%
Ingredients: Purified Water, Shea Butter, Glycerin, Sunflower Oil, Proprietary Nano Hemp Extract Formulation, Natural Oils & Minerals, Arnica.
Statements have not been evaluated by the Food and Drug Administration. Product not intended to diagnose, treat, cure or prevent disease.
Third-Party Laboratory Testing with “Track and Trace”
Confirmatory third-party lab testing is a key element of our “track and trace” system and confirms that our CBD products are exactly what we claim. We employ lab testing at all major stages including harvest, crystal isolate production, nano amplification and finished product. Each product undergoes rigorous testing to ensure product quality, consistency and purity documented by a Certificate of Analysis (COA) by product lot. The COA documents the chemical make-up, ingredients and purity of cannabinoids and other compounds, as well as ensure legal limits are met including confirmation that our products are THC free. Our testing also measures potency and ensures pesticides, residuals and pathogens are not present.
|Cool Relief Transdermal Cream Samples
What is CBD?
Cannabidiol (or “CBD”) is one of several chemical compounds called cannabinoids. CBD is derived from the Cannabis sativa plant. CBD is non-psychoactive and non-intoxicating.
What is the difference between hemp and marijuana?
While both hemp and marijuana come from the same family of plants, cannabis, and both contain CBD, they have vastly different chemical compositions. Marijuana has more than 0.3% THC in it (typically 5-30%), the psychoactive substance that causes a “high.” Marijuana is not legal in all states and is a Schedule I drug according to the DEA. Hemp has less than 0.3% THC in it and does not produce a “high.” Hemp and hemp-derived products are legal in most states following the passing of the 2018 Farm Bill.
What is the difference between conventional CBD and nano CBD?
Nano CBD allows more CBD to be absorbed at a quicker rate than conventional CBD. Cannabinoids are fat-based compounds that are difficult to break down and take time to absorb into the body. According to research studies, absorption rates of conventional CBD are only about 6%. Nano CBD is a process that reduces CBD into nano-sized particles that increase the absorption rate, so less is needed to have the same effect. Additionally, nano CBD is a water-based product that bypasses the typical breakdown and absorption processes, reducing the impact to your GI system, especially the liver.
Do CBD products contain THC?
Some CBD products do contain THC. BioNan-X nano-amplified CBD products do not contain THC and undergo confirmatory third-party lab testing.
Will patients test positive for THC while using CBD?
A recent pilot study demonstrated that patients won’t test positive for THC while using BioNan-X, because it contains “isolated” CBD without any THC. Additionally, BioNan-X CBD products are validated by third-party lab testing. However, it is possible to test positive with other companies’ CBD products that do have trace amounts of THC in them even if the THC is less than 0.3%.
Are there any intoxicating, psychoactive or psychotropic effects?
Unlike THC, which is the major active ingredient in marijuana, our hemp-derived, THC-free CBD does not give the user a “high” or euphoric feeling like marijuana.
What is the difference between distillate and isolate?
A distillate is the oil “distilled” out of the plant along with other compounds from the plant such as flavonoids and terpenes (which can give off an unpleasant taste or smell). Distillates contain THC—some have all the THC available in the plant and some only contain trace amounts. However, since distillates are oil-based, they are stored in fat molecules, where small amounts of THC can build up over time and cause a positive drug test. An isolate is when ONLY the CBD is extracted from the plant. This does involve a chemical process but ensures that there is no THC or any other plant compounds in the extract. Isolate is also flavorless and odorless, making it more pleasant to consume in drops or liquids.
What are “broad spectrum” and “full spectrum” CBD?
Broad spectrum and full spectrum CBD products are distillates from the hemp plant. Full spectrum CBD contains everything in the plant (including the legal limit of THC). Broad spectrum CBD is when the THC is taken out. However, it can still contain trace amounts of THC that will build up over time (since it is a lipid molecule and stored in the body’ in fat cells) and could still trigger a positive drug test. Broad and full spectrum products are promoted as providing the numerous benefits of the additional plant-based compounds, such as flavonoids, terpenes and other cannabinoids. This is called the “entourage effect.” However, CBD extracted from hemp has very low concentrations of all of these other compounds and they are unlikely to be enough to realize their benefits. It is important to check the certificate of analysis (COA) of these products to identify if the other compounds exist in high enough concentrations to have any beneficial effects. These benefits need to be weighed against the problem of having THC in it (either 0.3% or trace amounts) that could cause a positive test.
Does isolate mean you don’t have any of the other beneficial compounds from the plant?
No. Isolate means that you are getting pure CBD (99.9%) and nothing else that may cause unwanted effects such as THC. However, after we isolate the CBD and nano-emulsify it to make it more potent and easier to absorb, we add back in specific terpenes that can enhance the effect of the CBD. This enables us to more tightly control the contents of the product.
Is CBD legal?
Signed by President Trump on December 26, 2018, the 2018 Farm Bill legalized hemp-derived CBD at the federal level by removing it from the list of Schedule 1 controlled substances as long as it does not contain more than 0.3% THC. Compliance with the Farm Bill requires registration and licensing at the state level. While the majority of states have legalized CBD, it is not fully legal in all 50 states.
How do patients use CBD?
Depending on the type of product and delivery method, there are different ways to consume CBD. These include: 1) oral absorption or ingestion, 2) topical or transdermal application to the skin, and 3) inhalation.
What is the difference between topical and transdermal?
Topical creams have a local effect where they are placed, such as a corticosteroid cream for skin irritation. Transdermal creams are absorbed through the skin and enter the blood stream, having an effect elsewhere on the body. Transdermal applications may be preferred since they tend to have lower adverse reactions and interactions with other medications.
Will CBD interact with medications?
Depending on dosage and the type of medication and CBD the patient is taking, drug interactions are possible. Experts generally agree that the risk of having a serious drug interaction may be lower if you take your medications and CBD at different times of the day. Additionally, because nano-CBD provides an effect with a lower dose of CBD, it reduces the risk of interactions (versus conventional CBD which requires consumption of greater amounts to have the same effect).
What are the side effects of CBD?
Compared with NSAIDs and over-the-counter medicine, CBD has few side effects, which may include dry mouth, nausea, diarrhea, headaches, lethargy, change in appetite and hyperactivity. Experts recommend starting with a low dose to assess side effects. Nano-CBD may reduce the likelihood of these side effects since less is required to have an effect the body compared to conventional CBD.